Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
Antibody response and intra-host viral evolution after plasma therapy in COVID-19 patients pre-exposed or not to B-cell-depleting agentsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy Anti-spike anti-Spike IgG antibody antibody kinetics B-cell clinical care clinical status clinical symptom Complete contribute convalescent convalescent plasma COVID-19 patient Decline donors eligible evaluated Follow-up hospitalized COVID-19 patients humoral Humoral immunity IgG Immune escape Immunocompromised Immunocompromised patients Immunoglobulin impair lymphopenia majority management mRNA-based vaccine mRNA-based vaccine plasma mutation rate Patient patients treated plasma receiving SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2-specific antibodies severity spike mutations survival therapy titre viral control viral evolution virus clearance WHO whole-genome sequencing Whole-genome sequencing. World Health Organization [DOI] 10.1111/bjh.18450 PMC 바로가기
Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Administered analyzed CD4 CD8 cellular response Clinical outcome COVID-19 demonstrated effective evaluate Evolution flow cytometric group healthy controls immune memory Immunity Impact impair IMPROVE increases in individuals Infection initial investigated marker median memory memory T-cell response monoclonal antibodies monoclonal antibody neutralizing monoclonal antibody Patient patients patients treated patients with COVID-19 receiving SARS-CoV-2 significant increases in SOT spike statistically significant statistically significant difference T-cell Response T-cell response. treated Treatment Viral diseases were measured [DOI] 10.1016/j.ijid.2022.09.016 PMC 바로가기
Antibody response after COVID-19 vaccination in intravenous immunoglobulin-treated immune neuropathiesArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] SARS, 진단, [키워드] Administered administration age Alter analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibodies COVID-19 COVID-19 vaccination COVID-19 vaccine decrease dose enzyme-linked immunosorbent female healthy subjects IgA IgA titer IgG IgG titer IgM immune immunoassay Immunoglobulin impair indicate Interaction intravenous Intravenous immunoglobulin IVIG Microparticle mRNA vaccine observation Patient positive Prevalence reduce remained sera serological response serum serum titer significantly subsequent the antibody response therapeutic vaccination Vaccine vaccine dose vaccine interaction. [DOI] 10.1111/ene.15508 PMC 바로가기
Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIVArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Analysis Antibody Response CD4 CD4 cell CD4 count CD4 T-cell CD4 T-cell counts Cluster Complete COVID-19 vaccine COVID-19 vaccines determine dose evaluated Humoral response IgG IgG antibody immunization Immunosuppression impair individual log median mRNA multicentre neutralization Neutralizing antibodies Patient people living with HIV PLWH predictor Probability prospective cohort study quantitative determination receiving response to vaccination SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion Specific the antibody response the vaccine vaccination Vaccine vaccine. with HIV [DOI] 10.1016/j.cmi.2022.05.018 PMC 바로가기
Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumatic disease undergoing immunosuppressive therapy: A Japanese monocentric studyArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome addition Analysis analyzed Antibody titer attenuate Baricitinib BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Combination controls coronavirus coronavirus disease COVID-19 COVID-19 vaccine disease domain dose Glucocorticoids healthy volunteer humoral immune response immunomodulatory Immunosuppressant immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive medication impair inhibitor inhibitors interleukin-17 interleukin-6 investigated Japanese Kagawa methotrexate much lower Necrosis of BNT162b2 Outpatient Patient patients treated reduced rheumatic disease SARS-CoV-2 SARS-CoV-2 spike protein second dose serum serum antibody significantly significantly lower Spike protein the patient therapeutic agent Treatment university Vaccine [DOI] 10.1097/MD.0000000000031288 PMC 바로가기
Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severityArticle Published on 2022-10-072022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody autoantibody Blood blood pressure coronavirus COVID-19 develop disease severity distress domain dysregulation epitope hospitalized patient immune reaction impair induce life-threatening main entry receptor Oxygenation peptide proportion Protein RBD regulate Regulation SARS-CoV-2 spike the SARS-CoV-2 thought thrombosis with COVID-19 [DOI] 10.1126/sciadv.abn3777 PMC 바로가기
Serological response to SARS-CoV-2 vaccination in patients with inflammatory rheumatic disease treated with disease modifying anti-rheumatic drugs: A cohort study and a meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Joint bone spine [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome addition Antibody Response biologic Cohort cohort study conducted coronavirus COVID-19 COVID-19 pandemic disease evaluated identify IgG antibody immune-mediated diseases impair individuals Inflammatory Inflammatory rheumatic diseases IQR leflunomide less management median age Meta-analysis methotrexate observational study Older participant Patient performed Prevalence reported rheumatic disease rituximab robust Sample size SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV2 vaccination second vaccination seroconversion rate seroconversion rate. seroconverted serological response significantly Spike protein suggested targeted therapy Therapies therapy treated two-dose regimen vaccination Vaccine were measured [DOI] 10.1016/j.jbspin.2022.105380 PMC 바로가기
Association Between Maintenance Immunosuppressive Regimens and COVID-19 Mortality in Kidney Transplant RecipientsArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] 진단, [키워드] age association baseline baseline characteristics cardiovascular disease cohort study Comorbidity conducted coronavirus disease Corticosteroid COVID-19 death diabete died evaluated False positive form French high risk hypertension immune function Immunosuppression immunosuppressive immunosuppressive drug impair inhibitor kidney transplant Logistic regression lower risk maintenance mammalian men Mortality MOST multiple imputation Odds ratio outcome p value performed Rapamycin recipient recipients regimen registry retrieved risk of death serum creatinine significantly lower Solid solid organ solid organ transplant statistically significant Transplant was used with COVID-19 [DOI] 10.1097/TP.0000000000004254 PMC 바로가기